TMC7 and Abnormal sperm morphology: By generating Tmc7 conventional knockout mice (Tmc7–/–), we demonstrate that TMC7 deficiency leads to aberrant Golgi morphology and impaired fusion of Golgi-derived vesicles to the acrosome, thus resulting in male infertility with an oligo-astheno-teratozoospermia (OAT) phenotype.