TMC1 and deafness: Tmc1 and 2 are mechano-electrical transducer (MET) channels in cochlear hair cells, and mutations in Tmc1/2 cause deafness in humans and mice (Nist-Lund et al., 2019a) by disrupting hair cell mechanoelectrical transduction, and Tmc gene therapy can restore auditory function and balance in mice (Askew et al., 2015; Nist-Lund et al., 2019b).