IL4 and neoplasm: IL‐4, a classic anti‐inflammatory cytokine, can polarize macrophages to the M2 phenotype, thereby contributing to an immunosuppressive microenvironment for tumor growth.[53] Additionally, SKAP1 overexpression conferred resistance against NK cell cytotoxicity even in the absence of neutrophils, although this resistance was markedly less pronounced than that in the presence of neutrophils.