CXCL8 was initially identified as a monocyte‐derived neutrophil chemotactic factor.[46] Currently, CXCL8 is believed to be also secreted by cancer cells, including colorectal cancer cells,[47] and is involved in neutrophil migration into tumors.[48] Our results suggest that SKAP1 is an upstream positive regulator of CXCL8 in colon cancer cells and is dependent on NFATc1, a crucial member of the NFAT family, to regulate CXCL8 expression. Here, NFATC1 is linked to colonic neoplasm.