Furthermore, Ly6G+ cell depletion prolonged the survival of HCT116 tumor‐bearing mice and substantially weakened the adverse effects of SKAP1 overexpression on the survival of tumor‐bearing mice (Figure 3J), suggesting that SKAP1‐induced colon tumor promotion depends largely on the pro‐tumor activity of neutrophils. Here, SKAP1 is linked to colonic neoplasm.