We provide evidence, for the first time, that SKAP1 expression in cancer cells potently promotes the in vivo growth of colon tumors and further revealed that the cancer cell/neutrophil NFATc1/CXCL8/NET axis is the key mechanism contributing to the tumor‐promoting effect of SKAP1 (Figure 8). This evidence concerns the gene CXCL8 and colonic neoplasm.