SKAP1 expression in colon cancer cells significantly promoted neutrophil infiltration and NET formation, which largely contributed to the tumor‐promoting effect of SKAP1, via nuclear factor of activated T cells c1 (NFATc1)‐dependent C‐X‐C motif chemokine ligand 8 (CXCL8) expression. This evidence concerns the gene SKAP1 and neoplasm.