Additionally, NFATc1 knockdown in colon cancer cells largely abolished the NET‐enhancing effect of CM from SKAP1‐overexpressing cells in the in vitro NETosis assay (Figure 6F; Figure S5B, Supporting Information) and attenuated SKAP1‐induced proliferation enhancement of colon cancer cells in the cancer cell/HL‐60 co‐culture models (Figure 6G), suggesting the involvement of NFATc1‐dependent regulation of CXCL8 in the tumor‐promoting effect of SKAP1. Here, SKAP1 is linked to colonic neoplasm.