One of the first reports on this topic concerns the successful delivery of HER2 siRNA by chitosan nanoparticles with encapsulated green fluorescent CdSe/ZnS QDs, functionalized with anti-HER2 antibodies, as shown on SK-BR-3 HER2-overexpressing breast cancer cells and the MCF-7 line [272]. The gene discussed is ERBB2; the disease is breast carcinoma.