According to the literature review, this mutation is more prevalent and, moreover, strongly linked to undetectable levels of Factor IX or a severe clinical presentation in individuals with hemophilia B across diverse ethnic populations (Belvini et al., 2005; Ivaskevicius et al., 2001; Knobloch et al., 1993; Kulkarni et al., 2021; Kwon et al., 2008; Li et al., 2014; Mårtensson et al., 2016; Parrado Jara et al., 2020; Yu et al., 2012). This evidence concerns the gene F9 and hemophilia B.