The risk variants rs528002287 (locus 15q26.3) in PCSK6 and rs148010464 (locus 1q31.1) an intergenic variant in PLA2G4A/LINC01036 for stroke were unique to South Asia, and were found to be associated with cardioembolic stroke and small vessel stroke in South Asians (Kumar et al., 2021). Here, PCSK6 is linked to small vessel stroke.