FOLH1 and neoplasm: The lack of uptake within the submandibular and sublingual glands and reduced (37–42% of the wild-type) uptake in parotid glands of PSMA−/− mice suggest that the uptake in the salivary glands is still somehow primarily PSMA mediated, while nonspecific uptake may play a minor role.42 Establishing PSMA as the likely primary mediator of salivary gland uptake is important, given ongoing efforts to block this uptake, as well as the prognostic implications of salivary and tumor PSMA expression.43