ALOX12 and pulmonary edema: Notably, rHMGB1 treatment exacerbated lung injury in Alox12-KO mice after lung IR (Fig. 6A), as evidenced by increases in lung injury scores (Fig. 6C), airway resistance, PaCO2, microvascular permeability, and pulmonary edema and decreases in airway compliance, PaO2, and survival (Fig. S6A to F).