Notably, after genetically inhibiting Alox12 in mice, ferroptosis was dramatically inhibited compared with that in WT mice subjected to lung IR, as evidenced by decreases in ferric iron deposits, the levels of Fe2+ and MDA, and the increases in the GSH/GSSG ratio and the protein level of GPX4 (Fig. 3B to F). The gene discussed is GPX4; the disease is medical procedure.