The suppression of NGF-stimulated CGRP release via α2 receptor-mediated pathways and the observed effects of α2 antagonists in restoring CGRP levels further illustrate the intricate relationship between SNS signaling, CGRP regulation, and hypertension-related processes, which may mirror similar mechanisms in migraine pathogenesis (Supowit et al., 1998).Therefore, the increased risk of migraine with aura associated with adrenergic neuron blockers might stem from these drugs’ broad systemic effects on the SNS and CGRP regulation. Here, NGF is linked to hypertensive disorder.