For BCR-ABL-positive leukemia in mice, it was shown that knockout of 5-LO prevents CML induction, which seems to be due to a defect in leukemic stem cell proliferation and long-term survival in the absence of 5-LO (Chen et al., 2009). This evidence concerns the gene ALOX5 and chronic myelogenous leukemia, BCR-ABL1 positive.