In line with this, we could show that pharmacological inhibition of 5-LO by CJ-13,610 also affects the aberrant stem cell capacity in a PML/RARα-positive model of AML (acute myeloid leukemia) and a murine cancer stem cell (CSC) model (Roos et al., 2014). The gene discussed is RARA; the disease is acute myeloid leukemia.