PTGS1 and small intestine neoplasm: ApcMin/+ mice (an animal model bearing multiple intestinal neoplasia) with the specific deletion of Ptgs1 (protein name COX-1) in the megakaryocytes/platelets (mimicking the pharmacodynamics of low-dose aspirin in humans) were associated with a reduced number (67%) and size (29%) of tumors of the small intestine (Bruno et al., 2022).