SIRT1 and colonic neoplasm: Studies have also shown that the vitamin D active substance 1α,25-dihydroxyvitamin D+3 (1,25(OH)2D3, calcitriol) can promote SIRT1 activation in colon cancer cells, and SIRT1 activators may provide new therapeutic possibilities for patients with VD deficiency or non-response to colon cancer (Carding et al., 2015).