AKT1 and schizophrenia: In addition, study of animal models has suggested that the miR-25-3p-mediated TWIST1/PI3K/Akt/GSK3β signaling pathway is altered in the brain of schizophrenia model rat, and this alteration can be restored by RPD, indicating that this pathway might be a potential biomarker for SCZ and a possible target for antipsychotic treatment (Pan et al., 2023).