ERBB2 and neoplasm: TUBB3 is a microtubule protein with important roles in chromosome segregation during mitosis, which was shown to be overexpressed in some cancers in a cell-cycle dependent manner, its overexpression leading to resistance to taxane derivates (Shibazaki et al., 2012), advanced tumor stage, and HER2 amplification in patient cohorts (Lebok et al., 2016).