Our experimental data indicate that the upregulation of ACSL4 and M2 macrophage polarization markers (Arg1, CD163, CD206) have a significant correlation with the development of HBV‐HCC, while the expression of M1 markers (CD86, CD80, CD11c) is significantly downregulated (Figure S3). This evidence concerns the gene ARG1 and hepatocellular carcinoma.