To authenticate the regulatory function of ACSL4 in the initiation and progression of HCC through BAs and the FXR, we conducted experiments using human hepatic stellate cells (LX‐2) to measure the levels of ACSL4, BAs, and FXR, as well as their effects on the proliferation, migration, and invasive potential of HCC cells. The gene discussed is NR1H4; the disease is hepatocellular carcinoma.