Examination through RT‐qPCR and Western blot assays revealed that in HBV‐HCC tissues, the expression levels of ACSL4, CDKN3, SERPINE1, ANLN, MAD2L1, and THRSP were upregulated, while the expression levels of PTGS2, SPP1, TPR, and IDO2 were downregulated. Here, CDKN3 is linked to hepatocellular carcinoma.