Indeed, when coculturing glioblastoma spheroids together with vessel-forming HUVECs in the cancer-on-a-chip, the vessels showed increased ICAM-1 expression in the presence of both LV-Ctrl and LV-TF spheroids, whereas VE-cadherin expression was only increased in the U251 LV-TF condition (Figure 2). Here, CDH5 is linked to glioblastoma.