MTs play important roles in the regulation of metal homeostasis, detoxification of heavy metals, protection against oxidative stress, regulation of cell proliferation and death, and regulation of neuronal growth [17,18]. It was reported that MT-1 and MT-2 interact with osteopontin, an extracellular matrix protein with critical roles in autoimmune demyelinating diseases such as MS [19], and the interactions between two MTs and osteopontin improve tissue remodeling in encephalomyelitis [20]. Here, SPP1 is linked to encephalomyelitis.