The analysis revealed 1515 upregulated genes and 1877 downregulated genes, including vitamin D3 receptors. The VDR has garnered considerable attention in recent pan-cancer analyses, revealing its extensive implications across a variety of cancer types. These findings emphasize the importance of further exploring VDR's role as a prognostic marker and potential therapeutic target in CESC. Additionally, ongoing research continues to investigate the potential use of vitamin D analogs as adjuvant therapies for cancer. Here, VDR is linked to cancer.