It is important to note that two of the 10 patients included had a family history of FHA and two patients had two rare genetic variants in genes related to GnRH deficiency, Chromodomain Helicase DNA-binding Protein 7 (CHD7) and NMDA Receptor Synaptonuclear Signaling and Neuronal Migration Factor (NSMF) (74). Here, CHD7 is linked to hypoalphalipoproteinemia, primary, 1.