The previous studies have demonstrated the ability of fibrinogen to interact with secreted growth factors, such as transforming growth factor-β (TGF-β), fibroblast growth factor-2 (FGF-2), vascular growth factor (VEGF), and platelet-derived growth factor (PDGF) to stimulate tumor cell proliferation and angiogenesis (30–32). This evidence concerns the gene VEGFA and neoplasm.