In line with this, we have previously reported that endogenous CXCL10 can facilitate trafficking of CXCR3-expressing melanoma cells to bone, in which direct interactions between melanoma cells and macrophages can further stimulate CXCL10 amplification from macrophages to promote melanoma metastatic growth and subsequent osteolysis (Lee JH et al. 2012). This evidence concerns the gene CXCR3 and melanoma.