Immunohistochemical analysis further revealed that microvessel density, as evidenced by the intensity of CD31 expression, was considerably decreased in Cxcl10-/- mice than in WT mice (Figure 1(E)), event at an early stage (day 5) in which tumor sizes were comparable between WT and Cxcl10-/- mice. This evidence concerns the gene CXCL10 and neoplasm.