CXCL10 and cancer: The tumor microenvironment comprises heterogeneous populations, including infiltrating immune cells and stromal cells as well as cancer cells themselves (Binnewies et al. 2018), in which multiple cell types encompassing monocytes, endothelial cells, fibroblasts, inflammatory macrophages and dendritic cells, and cancer cells are responsible for CXCL10 production (Liu M et al. 2011; Tokunaga et al. 2018).