CXCL10 and neoplasm: To further determine whether CXCL10 could enhance tumor-induced angiogenesis in vitro as it upregulated expression of pro-angiogenic factors in B16F10 cells, we performed human umbilical vein endothelial cells (HUVECs) tube formation and proliferation assays using conditioned medium (CM) derived from CXCL10-treated B16F10 cells.