Besides, melanoma tumor clones highly intrinsic expressing CXCL10 can promote melanoma motility, metastasis, and metastatic tumor growth in an autocrine CXCL10/CXCR3 signaling-dependent manner (Wightman et al. 2015) and CXCR3-expressing melanoma cells can promote metastases to the lymph node, bone, and brain in a paracrine-dependent mode of CXCL10 action (Kawada et al. 2004; Lee JH et al. 2012; Doron et al. 2019). This evidence concerns the gene CXCR3 and melanoma.