In conclusion, our in vitro and in vivo findings showed that CXCL10 expressed by the host in response to melanoma tumor presence exerted pivotal functions in melanoma angiogenesis and vertical tumor growth by stimulating melanoma cancer cells to activate pro-angiogenic and pro-growth signals, which could lead to secretion of distinct pro-angiogenic factors contributing to endothelial cells-mediated angiogenesis and direct melanoma tumor growth. Here, CXCL10 is linked to neoplasm.