Mutations in CFTR cause the channelopathy cystic fibrosis, a genetic disorder that affects the lungs and other organs.47 The chloride–bicarbonate exchanger (CBE, also referred to as anion exchanger 1, AE1) exchanges chloride and bicarbonate ions across cell membranes and participates in carbon dioxide transport by red blood cells and pH regulation.48 Many other chloride channels (ClCs) and transporters play important roles and are linked to diseases such as myotonia congenita and Dent's disease.49 Altogether, anion transport is an indispensable facet of various biological processes. The gene discussed is SLC4A1; the disease is channelopathy.