Therefore, the current study was aimed at assessing the interactions between the lncRNA ILF3AS1, MMP3, MMP9, and miRNA-212 in children with epilepsy and healthy children to explore their roles as potential biomarkers and independent risk factors of epilepsy; these results were further correlated with the MRI features among children with epilepsy to better understand the pathogenesis of epilepsy and predict potential targeted therapies. Here, MMP3 is linked to epilepsy.