Therefore, the current study was aimed at assessing the interactions between the lncRNA ILF3AS1, MMP3, MMP9, and miRNA-212 in children with epilepsy and healthy children to explore their roles as potential biomarkers and independent risk factors of epilepsy; these results were further correlated with the MRI features among children with epilepsy to better understand the pathogenesis of epilepsy and predict potential targeted therapies. Here, ILF3-DT is linked to epilepsy.