We found that RBP4+ECs regulated the expression of 29 target genes in T cells by upregulating HMGB1 in the L group, including IFNG, which enhances tumor immune function and promotes T cell exhaustion (Benci et al., 2019), and CCL3, which facilitates dendritic cells (DC) recruitment for antigen presentation and T cell activation (Castellino et al., 2006). The gene discussed is RBP4; the disease is neoplasm.