VSIR and neoplasm: We found that many chemokine-mediated interactions were specifically present in the L group, such as the CCL4L2-VSIR, FCGR2A-CXCL9, CCL3L3-CCR1, CCL3L1-CCR11, IDE-CCL23, and CXCL11-DPP4, CCL2-CCR10 pathways which suggests that tumor cells in the L group might recruit more myeloid cells.