One example is TRIM25, an E3 ubiquitin ligase that has been demonstrated to enhance the proliferation, invasion and oxaliplatin resistance of CRC cells (Zhou et al., 2021), while the deubiquitinase USP7 has been implicated in CRC epithelial mesenchymal transition (Basu et al., 2023). Here, USP7 is linked to colorectal carcinoma.