TP53 and adrenal cortex carcinoma: In addition to the above tumors, we also found that HNRNPA2B1 expression in ACC, COAD, GBM, LGG, OV, STAD, LIHC, LUAD, SKCM, and UCS is closely related to spliceosomes, ribosomes, nucleocytoplasmic transport, p53-signaling pathway, RNA degradation, and surveillance pathway in addition to immune-related pathways, which indicates that HNRNPA2B1 plays an important role in both tumor development and immunotherapy (Supplementary figure 1).