Using the median expression value of HNRNPA2B1 as a cut-off value, we found significant differences in genetic alterations between high and low expression groups in several cancers, especially in some classical cancer-related genes, such as TP53, EGFR, IDH, etc. m1A, m5C, and m6A are the most well-studied RNA modification patterns that have been shown to play a critical role in the development of multiple cancers [7, 38]. Here, IDH2 is linked to cancer.