Especially in some classical cancer-related genes, such as TTN and TP53 in STAD (Figure 4(a)), APC and TP53 in COAD (Figure 4(b)), DST and HTT in CESC (Figure 4(c)), EGFR and IDH in GBMLGG (Figure 4(d)), TP53 and IL6ST in LIHC (Figure 4(e)), TP53 and BEAF in LUAD (Figure 4(f)), EGFR and IDH2 in LGG (Supplementary figure 1), APC and RB1 in OV (Supplementary figure 1), TP53 and TMPRSS2 in PRAD (Supplementary figure 1), NOTCH2 and CUBN in KIRP (Supplementary figure 1), and RUNX1 and MUC16 in LAML (Supplementary figure 1). This evidence concerns the gene IDH2 and prostate adenocarcinoma.