Consistent with previous studies that an EMT-TF Zeb1 controls the stemness of neural stem cells as well as cancer initiating cells (Ansieau et al., 2008; Chaffer et al., 2013; Gupta et al., 2021; Sabourin et al., 2009), Zeb1 expression was found in many Sox2+ neural stem/progenitors in the VZ of DG at E14 (Figures 2A1–A8). The gene discussed is SOX2; the disease is cancer.