CRH and neoplasm: Similarly, newly formed sympathetic nerves can be detected within breast cancer, which established a polysynaptic connection to the brain, then activated corticotropin-releasing hormone (CRH) neurons in the central medial amygdala (CeM) and promoted tumor growth through CeMCRH neurons and the CeMCRH → lateral paragigantocellular nucleus (LPGi) circuit (Xiong et al., 2023).