Hypothermia inhibits the production of free radicals by inhibiting superoxide and lipid peroxide [12]. Additionally, acute neuronal injury during cardiac arrest increases inflammatory cytokines IL-1β, IL-6, IL-18, and TNF, exacerbating neuronal damage [13]. Hypothermia reduces the production of these inflammatory cytokines while simultaneously increasing the production of anti-inflammatory cytokines [14]. The gene discussed is IL18; the disease is cardiac arrest.