According to Wu et al.’s systematic review and meta-analysis study on automatic evaluation of HER2 IHC status in breast cancer, the diagnostic performance of artificial intelligence (AI) shows high sensitivity and specificity with the diagnosis rendered by pathologists, and while these programs are able to distinguish between different HER2 IHC scores, the ability of AI to identify HER2 IHC scores of 2+ was slightly lower compared to recognition of scores of 0/1+ and 3+ [8]. This evidence concerns the gene ERBB2 and breast cancer.