Subsequently, the level of various inflammatory cytokines rises remarkably, including high mobility group box-1 protein (HMGB1), TNF-α, IL-8, IL-6, and IL-1β (89–92), which impair host defense against pathogens, alongside their crucial involvement in the excessive systemic inflammation and resultant damage to organs during sepsis (93). The gene discussed is IL1B; the disease is Sepsis.