Similarly, treatment with Ginsenoside Rb1 or fisetin (a natural flavonoid) mitigates the LPS-induced kidney damages by inhibiting IL-6, TNF-α, COX-2 expression, AKT activation and prevents from sepsis-mediated death in mice by down-regulating the MAPK signaling (40, 41). The gene discussed is TNF; the disease is Sepsis.