In terms of PD1 + immune cells, CD4 + T cells were more prevalent in LCC patients (18.7–51.6%) compared to RCC (5.82–20.7%), while PD1 + CD8 + T cells were more common in RCC patients (22.1–22.8%) compared to LCC (8.73–18.29%) (Figure 6B, Supplementary Table 10). The gene discussed is CD8A; the disease is leukoencephalopathy with calcifications and cysts.