Wilson et al. highlighted that in the ABCB5+ melanoma cell subpopulation purified by immunomagnetic selection and 3C2-1D12 antibody, ABCB5 is involved in WFDC1 repression (a repressor of the WNT signaling pathway) and IL-1β secretion, which maintains aggressiveness and communication with ABCB5- tumor cells through IL-1β/IL-8/CXCR1 signaling[53]. The gene discussed is CXCL8; the disease is melanoma.