A multicenter genome-wide association study (GWAS) showed that ABCB5 SNPs were associated with neurological instability in ischemic stroke, and mouse brain microvascular endothelial cells deprived of oxygen for 3h to mimic cerebral ischemia had an increased number of exosomes, extracellular vesicles secreted by various cell types, expressing ABCB5 protein[113,114]. The gene discussed is ABCB5; the disease is ischemic stroke.