Some studies have shown that the sodium content per gram of PRM is about four times higher than that of URM, and excessive sodium intake activates the renin-angiotensin (RAS) system, which increases the production of angiotensin-II, promotes inflammatory responses, increases peripheral vascular resistance, impairs arterial vascular compliance, and leads to elevated blood pressure, increased pulse pressure, and the development of hypertension (49, 50). This evidence concerns the gene REN and hypertensive disorder.