REN and Hypertension: Some studies have shown that the sodium content per gram of PRM is about four times higher than that of URM, and excessive sodium intake activates the renin-angiotensin (RAS) system, which increases the production of angiotensin-II, promotes inflammatory responses, increases peripheral vascular resistance, impairs arterial vascular compliance, and leads to elevated blood pressure, increased pulse pressure, and the development of hypertension (49, 50).