PDP1 and neoplasm: In recent years, dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase (PDK), has been shown to inhibit the inactivation of pyruvate dehydrogenase (PDH), the gating enzyme for the oxidative phosphorylation of glucose, which leads to inhibition of aerobic glycolysis, reduced lactic acid production in the tumor microenvironment, and increased mitochondrial membrane potential, which can inhibit the growth of tumor cells and achieve tumor suppression (6).