Statistical analysis did not demonstrate any noteworthy frequency distribution differences between different genotypes of the three H19 SNPs and patient age, menopausal status, tumor size, family history, clinical staging, lymph node metastasis, ER status, PR status, HER2 status, triple-negative breast cancer status, P53 status, and BRCA1 and BRCA2 status (P > 0.05). The gene discussed is ESR1; the disease is metastasis.