Regardless of breast cancer subtype, overexpression of the following mRNAs was observed: HRH1, HRH2, HRH4, HNMT, EDN1, EDNRA, HTR6, GABRB1, ADCYAP1, ADA, and SLC23A2. In turn, the expression profiles of mRNA, GNRH2, and PER2 were reduced in the tumor tissues compared to the controls. This evidence concerns the gene EDN1 and breast carcinoma.