In CRC, which ranks as the second leading cause of cancer-related deaths globally, lncRNAs like LINC00239 fosters CRC cell proliferation by interacting with Keap1, thereby disrupting the Keap1/Nrf2 complex and consequently bolstering Nrf2 protein stability, which results in its translocation to the nucleus (163, 164). The gene discussed is KEAP1; the disease is cancer.