Another gene alteration that was found in this patient’s tumor – PBRM1 inactivation – may predict the benefit of ICI targeting PD-1, such as nivolumab, pembrolizumab, cemiplimab, or dostarlimab, for patients with clear cell renal cell carcinoma and previous antiangiogenic therapy (37). This evidence concerns the gene PBRM1 and clear cell renal carcinoma.