In a study by Huang K et al. (23), utilizing the WGCNA approach, it was discovered that STAT4, CX3CR1, COL1A2, and SH2D1B, with STAT4 and COL1A2 being significant mechanisms implicated in the co-morbidities of heart failure and depression, offer new targets for investigating the pathogenesis of heart failure and depression, as well as for treating these conditions. Here, SH2D1B is linked to major depressive disorder.