CD4 and Cowden syndrome 1: In the study by Simone et al. (29), they analyzed the percentages of CD2 + T-bet + T cells and CD4 + GATA7 + T cells in the peripheral blood from patients with atherosclerotic thrombosis and CS, suggesting that circulating CD4 + T-bet + T cells might act as biomarkers for atherosclerotic thrombosis, indicating CS, and offering new perspectives on peripheral adaptive immune responses in acute stroke.