In the study by Simone et al. (29), they analyzed the percentages of CD2 + T-bet + T cells and CD4 + GATA7 + T cells in the peripheral blood from patients with atherosclerotic thrombosis and CS, suggesting that circulating CD4 + T-bet + T cells might act as biomarkers for atherosclerotic thrombosis, indicating CS, and offering new perspectives on peripheral adaptive immune responses in acute stroke. This evidence concerns the gene CD2 and Cowden syndrome 1.