PRKN and acute myocarditis: Collectively, these results clearly indicate that Parkin-mediated mitophagy was significantly increased in mouse hearts with CVB3-induced acute myocarditis, but also blocked autophagic flux at the late stages of autophagosome maturation, and that Parkin silencing to decrease the overall mitophagy activity in hearts is associated with CVB3-induced vulnerability to cardiac dysfunction and survival.