CD163 and nasopharyngeal carcinoma: In addition to the increased level of CD206 positive M2 subtypes in EBV-associated NPC, we found that the predominant macrophage subtypes were CD163-positive M2 subtypes macrophages, which can be defined as M2c macrophage 21, 22 based on evidence of combination CSF-1 stimulation, not only in EBV-associated NPC but also in EBVaGC.