B4GALT1, a glycosyltransferase, is mainly responsible for the biosynthesis of glycan structure Galβ1,4-GlcNAc, is up-regulated in gemcitabine-resistant pancreatic cancer patient-derived organoids and chemoresistant cell lines, and depletion of B4GALT1 reverses the chemoresistance to gemcitabine 9. The gene discussed is B4GALT1; the disease is familial pancreatic carcinoma.