Notably, chemokines like CCL1, CCL2, CCL4, CCL5, CCL11, CXCL8, CXCL10, and CX3CL1 are implicated in T2D pathogenesis, affecting immunoregulation, inflammatory gene induction, and insulin signaling modulation (50). The gene discussed is CCL4; the disease is type 2 diabetes mellitus.