Vaccination with MVA-S(3P), MVA-S(3Pbeta), MVA-S(3P_BA.1), or a bivalent MVA-S(3P)/MVA-S(3P_BA.1) combination protected K18-hACE2 transgenic mice against infection by SARS-CoV-2 Omicron BA.1 variant. The gene discussed is KRT18; the disease is infection.