Furthermore, iNKT cells have been shown to mediate potent anti-tumor immunity (14, 97, 98) by a range of different mechanisms like direct cytotoxicity (99, 100), lysis of tumor promoting immune cell subsets (101), or creating a tumor suppressive immune environment by stimulation of NK cells or CD8 T cells via IFNγ release and DC maturation, respectively (96, 102). This evidence concerns the gene CD8A and neoplasm.