As described by Leiding and Holland, HPV infection that becomes severe and recalcitrant to treatment is common to primary immunodeficiencies such as warts, hypogammaglobulinemia, infections, myelokathexis (WHIM), idiopathic CD4 lymphopenia, dedicator of cytokinesis 8 (DOCK8) deficiency and Emberger syndrome to name a few (11). The gene discussed is DOCK8; the disease is inborn error of immunity.