(1) Induces dose-dependent secretion of IFN-γ, IL-2, TNF-α, and MIP-1α(2) Enhances the cytolytic activity against OVCAR3 cells.(3) Long-term engraftment of B7-H4 CAR T cells mediates lethal, off-tumor toxicity. The gene discussed is VTCN1; the disease is neoplasm.