We also performed differential gene expression analysis between the adult human ALL Erythroid cells and the adult normal Bone Marrow Erythroid cells and observed the significant down-regulation of the S100A9 antibacterial immunity gene expression in the late Erythroid cells (Poly Eb, Ortho Eb, ARG1+ Ortho Eb); and the significant up-regulation of the MZB1 gene expression in the Ortho Eb (Figures 5B, C). The gene discussed is S100A9; the disease is acute lymphoblastic leukemia.