By utilizing JNK inhibitors like SP600125 to suppress JNK activity, the growth and dissemination of tumor cells in cancer models such as breast, pancreatic, and lung cancer can be inhibited, thereby demonstrating preventive and therapeutic effects against a variety of cancers (Takahashi et al., 2013; Joo et al., 2017; Xu et al., 2017; Li et al., 2020). This evidence concerns the gene MAPK8 and cancer.