To assess whether overexpression of reprogramming factors is sufficient to ameliorate age-associated cognitive decline inC. elegans, we created a strain expressing theC. elegansorthologs of the OSK factors (Oct4 =ceh-6, Sox2 =sox-2, Klf4 =klf-3)(Hsieh et al., 2017; Kagias et al., 2012)under the control of a neuron-specific doxycycline inducible promoter(Mao et al., 2018)(Figure 1A). This evidence concerns the gene SOX2 and Mental deterioration.