administered a combination of inosine + CpG + anti‐CTLA‐4 in mouse models of colorectal, melanoma, and bladder cancer, all of which showed that inosine enhanced the antitumor immunity of anti‐CTLA‐4 in the presence of the co‐stimulatory factor CPG.26, 43. The gene discussed is CTLA4; the disease is melanoma.