In regard to tumor immunity, inosine increases the tumor cell immunogenicity32, 33 and significantly upregulates the activation of interferon‐γ (IFN‐γ) and tumor necrosis factor‐α (TNF‐α) signaling pathways, whereby IFN‐γ can heighten antigen presentation.33, 34. The gene discussed is IFNG; the disease is neoplasm.